Thermo Fisher Scientific CD26 (DPP IV/ADA-Binding Protein) Monoclonal Antibody (DPP4/910)
CD26(DPP IV/ADA-Binding Protein) 인식 단클론 항체로 인간 및 랫트 반응성. IHC, ICC/IF, Flow Cytometry에 사용 가능. 비결합형 액상 형태로 200 µg/mL 농도, 4°C 보관. T세포 활성화 및 면역반응 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Frozen) (IHC (F)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Host/Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | DPP4/910 |
| Immunogen | Recombinant human DPP4 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Does not react with Pig or Sheep.
Target Information
CD26 (dipeptidyl peptidase IV, DPP IV; adenosine deaminase (ADA) binding protein) is a homodimeric atypical serine protease belonging to the prolyl oligopeptidase family. It is expressed on lymphocyte cells and upregulated during T-cell activation, also found on activated B cells, natural killer cells, and epithelial cells.
CD26 is involved in various biological functions including:
- T-cell activation
- Cell adhesion with extracellular matrix proteins (e.g., fibronectin, collagens)
- HIV infection processes
CD26 is identical to adenosine deaminase complexing protein-2 and the T-cell activation antigen CD26. It acts as a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. Alterations in CD26 peptidase activity are associated with malignant transformation and increase with tumor grade and severity. CD26 expression changes have been observed on circulating monocytes and CD4+ T cells during rheumatoid arthritis and systemic lupus erythematosus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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