Thermo Fisher Scientific Thrombomodulin/CD141 Recombinant Mouse Monoclonal Antibody (rTHBD, 1591)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1–2 µg/mL

Peptide Array (Array)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

• For IHC (PFA fixed): Incubate antibody for 30 minutes at room temperature.
• Formalin-fixed tissues require heat-induced epitope retrieval:
  • Heat in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C.
  • Cool at room temperature for 20 minutes before staining.

Target Information

Thrombomodulin (TM), also known as Fetomodulin (FM), endothelial anticoagulant protein, or glycoprotein P112, is a membrane glycoprotein expressed on endothelial cells.
It contains six EGF-like domains and a lectin-like N-terminal domain. TM accelerates activation of protein C, contributing to thrombo-resistance and reduction of clot formation.
Immunohistochemical detection of TM is useful in the study of various vascular tumors, meningiomas, and choriocarcinomas.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.