Thermo Fisher Scientific Phospho-MYL12A (Ser19) Polyclonal Antibody
Phospho-MYL12A (Ser19) 폴리클로날 항체로 인간, 마우스, 랫트 시료에 반응. Western blot 및 Immunocytochemistry에 적합. 항원 친화 크로마토그래피로 정제된 고품질 항체. 세포 수축 및 DNA 손상 복구 관련 연구에 활용 가능.
- 카탈로그번호
- PA5143727
- 판매단위
- pk
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Thermo Fisher Scientific Phospho-MYL12A (Ser19) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Phospho-MLC (Ser-19) synthetic peptide (coupled to KLH) corresponding to amino acid residues surrounding Ser-19 in human myosin regulatory light chain 12A (Myl12A). Highly conserved in human, rat, mouse, chicken, and zebrafish Myl12A, and other smooth muscle and non-muscle MLCs. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2942955 |
Product Specific Information
This antibody was cross-adsorbed to MLC (a.a. 11-22) then affinity purified using phospho-MLC (Ser-19) peptide (without carrier).
It detects a 20 kDa band corresponding to the molecular weight of myosin light chain in human A431 treated with EGF and in mouse C2C12 treated with Calyculin A.
Reactivity is lost after lambda phosphatase treatment of MLC.
Target Information
This gene encodes a nonsarcomeric myosin regulatory light chain activated by phosphorylation, regulating smooth muscle and non-muscle cell contraction.
It may also participate in DNA damage repair by sequestering the transcriptional regulator AATF/Che-1, which represses p53-driven apoptosis.
Alternate splicing results in multiple transcript variants.
A pseudogene of this gene is found on chromosome 8.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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