Thermo Fisher Scientific Leptin Receptor (LEPR)/Ob-R/CD295 Monoclonal Antibody (LEPR, 4301)
인간 Leptin Receptor(LEPR/CD295)를 인식하는 Mouse monoclonal 항체로, IHC 및 Peptide Array에 적합합니다. 단백질 A/G로 정제된 액상형 항체이며, 보존제가 없는 PBS(pH 7.4)에 저장됩니다. 에너지 항상성 및 비만 관련 연구에 활용 가능합니다.
- 카탈로그번호
- 3953-MSM1-P1ABX
- 판매단위
- pk
카탈로그
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | LEPR, 4301 |
| Immunogen | Recombinant fragment (around aa335–425) of human LEPR protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C or -80°C if preferred |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For immunohistochemistry (PFA fixed): Incubate antibody for 30 min at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 min at 95°C, followed by cooling at room temperature for 20 min.
Target Information
The leptin (OB-R) receptor is a member of the cytokine receptor superfamily involved in mammalian body weight homeostasis and energy balance. Activation by leptin triggers downstream signaling via the JAK/STAT pathway. Multiple isoforms differing in signaling capacity exist. Long-form OB-R transcripts are found in the choroid plexus and hypothalamus, key regions for satiety and energy regulation. Mutations in OB-R (db) or leptin (ob) genes cause early-onset obesity and metabolic abnormalities such as hyperinsulinemia, insulin resistance, and increased adipose tissue.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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