Thermo Fisher Scientific Leptin Receptor (LEPR)/Ob-R/CD295 Monoclonal Antibody (LEPR, 4301)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1–2 µg/mL

Peptide Array (Array)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

• For immunohistochemistry (PFA fixed): Incubate antibody for 30 min at room temperature.
• Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 min at 95°C, followed by cooling at room temperature for 20 min.

Target Information

The leptin (OB-R) receptor is a member of the cytokine receptor superfamily involved in mammalian body weight homeostasis and energy balance. Activation by leptin triggers downstream signaling via the JAK/STAT pathway. Multiple isoforms differing in signaling capacity exist. Long-form OB-R transcripts are found in the choroid plexus and hypothalamus, key regions for satiety and energy regulation. Mutations in OB-R (db) or leptin (ob) genes cause early-onset obesity and metabolic abnormalities such as hyperinsulinemia, insulin resistance, and increased adipose tissue.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 없음)