Thermo Fisher Scientific Leptin Receptor (LEPR)/Ob-R/CD295 Monoclonal Antibody (LEPR/4545)
인간 Leptin Receptor(LEPR/Ob-R/CD295)을 특이적으로 인식하는 Mouse Monoclonal Antibody입니다. IHC(P), IHC(PFA), Peptide Array 등 다양한 응용에 사용 가능하며, 단백질 A/G로 정제된 액상 형태로 제공됩니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific Leptin Receptor (LEPR)/Ob-R/CD295 Monoclonal Antibody (LEPR/4545)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | LEPR/4545 |
| Immunogen | Recombinant fragment (around aa335–425) of human LEPR protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The leptin (OB-R) receptor is a member of the cytokine receptor superfamily, playing an important role in mammalian body weight homeostasis and energy balance. Activation of OB-R by leptin triggers downstream signaling through the JAK/STAT pathway. Leptin can homo-dimerize OB-R extracellular domains, initiating intracellular signaling. Several OB-R isoforms with differing signaling capabilities have been identified. RNA transcripts encoding the OB-R long form are found in the choroid plexus and hypothalamus, proposed as centers for satiety and energy regulation. Mutations in mouse OB-R (db) or leptin (ob) genes lead to early-onset obesity and associated metabolic abnormalities such as hyperinsulinemia, insulin resistance, hyperglycemia, and increased adipose tissue.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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