Thermo Fisher Scientific TLK2 Monoclonal Antibody (OTI2H2), TrueMAB

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:500

Flow Cytometry (Flow)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

TLK2 (Tousled-like kinase 2) is a nuclear serine/threonine kinase involved in chromatin assembly regulation and other cellular processes such as intracellular signaling, protein phosphorylation, cell cycle control, and DNA damage response.
TLK2 exhibits maximal activity during S phase and is regulated by cell-cycle-dependent phosphorylation. DNA replication inhibition leads to rapid TLK2 activity loss, indicating a strong link between TLK2 function and DNA replication.
TLK2 is inactivated by phosphorylation at Ser-750, potentially by CHK1, and forms heterodimers with TLK1. It is widely expressed in fetal and adult tissues including placenta, liver, kidney, pancreas, heart, and skeletal muscle.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.