Thermo Fisher Scientific Periostin (POSTN) Recombinant Rabbit Monoclonal Antibody (POSTN/8523R)
Recombinant rabbit monoclonal antibody against human Periostin (POSTN), validated for IHC applications. High specificity clone POSTN/8523R, expressed in HEK293 cells. Supplied unconjugated in PBS buffer, suitable for research use only.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | POSTN/8523R |
| Immunogen | Recombinant fragment (around aa193–326) of human POSTN protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | −20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
Periostin (PN), also known as osteoblast-specific factor 2 (OSF-2), is a disulfide-linked protein originally identified as an osteoblast-specific factor. It is a secreted protein that binds heparin and functions as a ligand for αVβ3 and αVβ5 integrins. In preosteoblasts, Periostin acts as a cell adhesion molecule, contributing to osteoblast recruitment, spreading, and attachment.
Periostin is mainly expressed in the lower gastrointestinal tract, aorta, stomach, placenta, uterus, and breast tissues, and is upregulated in epithelial ovarian tumors and overexpressed in breast cancer. Its expression increases in response to bone morphogenetic protein (BMP2) and transforming growth factor beta 1 (TGF-β1). Structurally, Periostin contains a signal sequence, a cysteine-rich domain, four fasciclin-like repeats, and a C-terminal domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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