Thermo Fisher Scientific Periostin (POSTN) Recombinant Rabbit Monoclonal Antibody (POSTN/8523R)
Recombinant rabbit monoclonal antibody against Periostin (POSTN), validated for IHC applications. High specificity for human POSTN, expressed in HEK293 cells. Supplied unconjugated in PBS buffer with BSA and sodium azide. Ideal for research use in canc...
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | POSTN/8523R |
| Immunogen | Recombinant fragment (around aa193–326) of human POSTN protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Periostin (PN), also known as osteoblast-specific factor 2 (OSF-2), is a disulfide-linked protein originally identified as an osteoblast-specific factor. It is a secreted protein that binds heparin and functions as a ligand for α(V)β(3) and α(V)β(5) integrins. In preosteoblasts, Periostin acts as a cell adhesion molecule and contributes to osteoblast recruitment, spreading, and attachment.
Periostin is primarily found in the lower gastrointestinal tract, aorta, stomach, placenta, uterus, and breast tissues. It is upregulated in epithelial ovarian tumors and overexpressed in breast cancer. Expression is induced by bone morphogenetic protein 2 (BMP2) and transforming growth factor beta 1 (TGF-β1).
The Periostin protein includes a signal sequence, a cysteine-rich domain, four fasciclin-like repeated domains, and a C-terminal domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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