Thermo Fisher Scientific Transthyretin Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000
• Publications: View 2 publications

Immunohistochemistry (IHC)

• Tested Dilution: –
• Publications: View 2 publications

Product Specifications

Product Specific Information

• Recommended positive controls: Human plasma, Mouse liver, Rat plasma
• Predicted reactivity: Mouse (81%), Rat (82%), Cat (85%), Pig (87%), Sheep (85%), Rhesus Monkey (93%), Chimpanzee (97%), Bovine (85%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Transthyretin (TTR), also known as prealbumin, is a plasma protein that functions as a transporter of thyroxine and retinal-binding protein. It is primarily produced in the liver and secreted into plasma. TTR constitutes about 25% of CSF protein, suggesting selective transport across the blood-CSF barrier or synthesis within the CNS. It is found in neuritic plaques, neurofibrillary tangles, and microangiopathic lesions of senile cerebral amyloid. Over 40 mutations in the TTR gene have been associated with amyloid deposition.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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