Thermo Fisher Scientific TDP-43 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended positive controls: H1299, HeLa, mouse brain
• Predicted reactivity: Mouse (96%), Chicken (94%), Bovine (98%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

TDP43 was first identified as a novel cellular protein that binds to HIV-1 TAR DNA sequence motifs and acts as a transcriptional repressor to the HIV-1 LTR. It also regulates splicing of exon 9 of the cystic fibrosis transmembrane conductance regulator (CFTR), likely through association with UG repeats at the 3' splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43, known as pathologic TDP43, is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, an RNA-binding protein that binds HIV-1 TAR RNA sequences.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.