Thermo Fisher Scientific Factor VIII Recombinant Rabbit Monoclonal Antibody (610)

Applications

• ELISA (ELISA)
  Tested Dilution: 1:5,000–1:10,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to larger rabbit immune repertoire

This antibody has specificity for Human Coagulation Factor VIII/FVIII/F8.

Target Information

The gene encodes coagulation factor VIII, a cofactor in the intrinsic pathway of blood coagulation. Factor VIII acts with factor IXa, Ca²⁺, and phospholipids to convert factor X to its activated form Xa.

Two alternatively spliced transcripts are produced:

1. Transcript variant 1 (isoform a): Large glycoprotein circulating in plasma, forms a noncovalent complex with von Willebrand factor.
2. Transcript variant 2 (isoform b): Small protein primarily consisting of the phospholipid-binding domain essential for coagulant activity.

Defects in this gene result in Hemophilia A, a common recessive X-linked coagulation disorder.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.