Thermo Fisher Scientific PTX3 Polyclonal Antibody
PTX3 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, WB, IHC, ICC/IF에 사용 가능. 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 고순도 항체. 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the N-terminal of human PTX3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553399 |
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 41 kDa.
Purity is >95% by SDS-PAGE.
Target Information
Pentraxins are a protein superfamily characterized by a cyclic multimeric structure. PTX3, also known as tumor necrosis factor-stimulated gene sequence-14 (TSG14), is a secreted pattern-recognition receptor with a non-redundant role in resistance to selected microbial agents.
PTX3 belongs to the family of long pentraxins, which have C-terminal pentraxin domains and novel amino-terminal domains. It binds selected pathogens, including Aspergillus fumigatus, Pseudomonas aeruginosa, and Salmonella typhimurium.
PTX3 is synthesized in IgA glomerulonephritis and activates mesangial cells. Secretion in adipose cells can be induced by TNF. PTX3 is involved in amplification of inflammatory reactions and regulation of innate immunity.
The human PTX3 gene maps to chromosome 3q25.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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