Thermo Fisher Scientific GITR (TNFRSF18) Recombinant Rat Monoclonal Antibody (YGITR765)
마우스 GITR 단백질을 인식하는 랫트 유래 재조합 단클론 항체. Flow Cytometry 및 Inhibition Assay에 사용 가능. HEK293 세포에서 발현된 IgG2b, kappa 형식의 비결합 항체. Protein A로 정제되어 1 mg/mL 농도로 제공. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: Assay-dependent
Inhibition Assays (IA)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG2b, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | YGITR765 |
| Immunogen | nB2/6TG cells transfected with mouse GITR injected into DA rats |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
This antibody binds murine GITR.
Target Information
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also known as GITR or AITR, is a protein encoded by the TNFRSF18 gene in humans. It is mapped to chromosome 1p36.33 and encodes a member of the TNF-receptor superfamily. The receptor shows increased expression upon T-cell activation and plays a key role in maintaining immunological self-tolerance via CD25(+)CD4(+) regulatory T cells. Knockout studies in mice indicate its involvement in CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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