Thermo Fisher Scientific SQSTM1 Polyclonal Antibody
SQSTM1 단백질을 인식하는 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF 등 다양한 응용 가능. Human, Mouse, Rat 반응성. 항원 친화 크로마토그래피로 정제, 1 mg/mL 농도의 액상 형태. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5–2 µg/mL | View 15 publications |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–5 µg/mL | – |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 20 µg/mL | – |
| Immunocytochemistry (ICC/IF) | 20 µg/mL | View 6 publications |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse, Rodent |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 13 amino acid synthetic peptide from near the carboxy terminus of human SQSTM1. The immunogen is located within the last 50 amino acids of SQSTM1. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11157045 |
Product Specific Information
- Suggested positive controls: mouse skeletal muscle, mouse pancreas, or rat liver tissue lysates
- PA5-20839 can be used with blocking peptide PEP-0953
- Tested applications: Western Blot (human, mouse), Immunofluorescence and Immunohistochemistry (human, mouse, rat)
- Other applications and species not yet tested
Target Information
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-κB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-κB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified. Mutations in this gene are associated with sporadic and familial Paget disease of bone.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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