Thermo Fisher Scientific COX10 Polyclonal Antibody
Human COX10 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot 및 IHC(Paraffin) 분석에 적합. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human COX10. Recombinant protein control fragment (Product # RP-95548) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2640085 |
Product Specific Information
Immunogen sequence:
PNEKELIELE PDSVIEDSID VGKETKEEKR WKEMKLQVYD LPGILARLS
Sequence identity:
Highest antigen sequence identity to the following orthologs:
- Mouse: 65%
- Rat: 59%
Target Information
Defects in COX10 are a cause of mitochondrial complex IV deficiency (MT-C4D), also known as cytochrome c oxidase deficiency.
This disorder affects the mitochondrial respiratory chain and exhibits diverse clinical manifestations, from isolated myopathy to severe multisystem disease involving multiple tissues and organs.
Common features include hypertrophic cardiomyopathy, hepatomegaly, liver dysfunction, hypotonia, muscle weakness, exercise intolerance, developmental delay, and mental retardation.
A subset of patients may present with Leigh syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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