Thermo Fisher Scientific FAS Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.1–0.3 µg/mL
• Publications: [References]

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 3.75 µg/mL
• Publications: [References]

Product Specifications

Product Specific Information

This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.

Target Information

FAS (Fas, CD95, APO-1) is a 46 kDa transmembrane glycoprotein functioning as a cell death receptor of the TNFR superfamily. A soluble form (~26 kDa) also exists.
Activation of FAS leads to aggregation of FADD, formation of the death-inducing signaling complex (DISC), and activation of caspases, triggering apoptosis.
FAS has been shown to activate NF-kappaB, MAPK3/ERK1, MAPK8/JNK, and is involved in proliferative signaling in fibroblasts and T cells.
Multiple alternatively spliced variants exist; those lacking the transmembrane domain may negatively regulate apoptosis mediated by the full-length isoform.
The Fas/Fas ligand system is implicated in diseases such as AIDS, hepatitis, and cancer, and plays a key role in antiviral immune responses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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