Thermo Fisher Scientific FAS Polyclonal Antibody
FAS 단백질을 인식하는 염소 유래 폴리클로날 항체로, Western blot과 IHC(Paraffin)에 적합합니다. 합성 펩타이드 면역원 기반으로 제작되었으며, 고순도 액상 형태로 제공됩니다. 세포 사멸 관련 연구용으로 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.1–0.3 µg/mL
- Publications: [References]
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 3.75 µg/mL
- Publications: [References]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (KTCRKHRKENQGSH) corresponding to internal amino acids of FAS (aa 197–211) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10989343 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.
Target Information
FAS (Fas, CD95, APO-1) is a 46 kDa transmembrane glycoprotein functioning as a cell death receptor of the TNFR superfamily. A soluble form (~26 kDa) also exists.
Activation of FAS leads to aggregation of FADD, formation of the death-inducing signaling complex (DISC), and activation of caspases, triggering apoptosis.
FAS has been shown to activate NF-kappaB, MAPK3/ERK1, MAPK8/JNK, and is involved in proliferative signaling in fibroblasts and T cells.
Multiple alternatively spliced variants exist; those lacking the transmembrane domain may negatively regulate apoptosis mediated by the full-length isoform.
The Fas/Fas ligand system is implicated in diseases such as AIDS, hepatitis, and cancer, and plays a key role in antiviral immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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