Thermo Fisher Scientific c-Abl Polyclonal Antibody
Rabbit polyclonal antibody targeting human c-Abl protein; validated for WB and ICC/IF; supplied unconjugated in liquid form at 1 mg/mL; ideal for studying ABL1 signaling and oncogenic processes; for research use only.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues 700–800 of an internal portion of human c-ABL (Swiss-Prot# P00519) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Wet ice |
| RRID | AB_1956468 |
Product Specific Information
Suggested positive control: antigen standard for ABL1 (transient overexpression lysate), K562 whole cell lysate.
Target Information
The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase involved in cell differentiation, division, adhesion, and stress response. Activity of c-Abl is negatively regulated by its SH3 domain; deletion converts it into an oncogene. Its DNA-binding activity is regulated by CDC2-mediated phosphorylation, suggesting a role in the cell cycle. In chronic myelogenous leukemia and some acute lymphoblastic leukemias, c-Abl undergoes a (9;22) translocation forming the Philadelphia chromosome, fusing c-Abl sequences from chromosome 9 with the Bcr gene on chromosome 22. The c-Abl oncogene was first identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). c-Abl may regulate DNA repair by activating proapoptotic pathways when DNA damage is irreparable.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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