Thermo Fisher Scientific CD59 Recombinant Mouse Monoclonal Antibody (193-27)
CD59 단백질을 인식하는 Thermo Fisher Scientific의 마우스 유래 재조합 단클론 항체입니다. IHC, ICC/IF, Flow Cytometry 등 다양한 응용에 적합하며, 인간 시료에 반응합니다. 액상 형태로 제공되며, 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: Assay-dependent
Immunocytochemistry (ICC/IF)
- Tested Dilution: Assay-dependent
Flow Cytometry (Flow)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgM, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 193-27 |
| Immunogen | This antibody was raised by immunizing mice with stimulated human leukocytes. Target family: CD59, UniProt ID: P13987-1, Antigen range: 1–128 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
This antibody recognizes human CD59, a glycosyl phosphatidyl-inositol (GPI)-anchored cell surface protein. It regulates complement-mediated cell lysis and is involved in lymphocyte signal transduction.
Target Information
CD59 (Protectin) is a small (18–20 kDa) GPI-anchored, ubiquitously expressed inhibitor of the membrane attack complex (MAC). It protects autologous cells from complement-mediated lysis by binding C8 and/or C9, preventing cytolytic pore formation. CD59 also acts as a low-affinity ligand for CD2, contributing to T-cell costimulation and lymphocyte signal transduction. Mutations in CD59 cause deficiency leading to hemolytic anemia, thrombosis, and cerebral infarction. Multiple alternatively spliced transcript variants of CD59 have been identified.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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