Thermo Fisher Scientific CD7 Recombinant Mouse Monoclonal Antibody (3A1E)
인간 CD7을 인식하는 재조합 마우스 단클론 항체로, Flow Cytometry와 Functional Assay에 사용 가능. HEK293 세포에서 발현되며 Protein A로 정제됨. 액상 형태로 1 mg/mL 농도, PBS 버퍼 및 ProClin 300 포함. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: Assay-dependent
Functional Assay (Functional)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 3A1E |
| Immunogen | CD7 expressing cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
Recognises human CD7.
Target Information
CD7 (gp40, Leu9) is a 40 kDa member of the immunoglobulin gene superfamily.
CD7 contains N-terminal amino acids (1–107) that are highly homologous to Ig kappa-L chains, while the carboxy-terminal region of the extracellular domain is proline-rich and may form a stalk from which the Ig domain projects.
CD7 is expressed on most immature and mature T-lymphocytes and T cell leukemia cells. It is also found on natural killer cells, a small subset of normal B cells, and malignant B cells.
Cross-linking surface CD7 positively modulates T cell and NK cell activity, influencing calcium fluxes, adhesion molecule expression, cytokine secretion, and proliferation.
CD7 associates directly with phosphoinositol 3′-kinase, and its ligation induces D-3 phosphoinositide production and tyrosine phosphorylation.
Expression of CD7 is an important marker used in leukemia diagnostics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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