Thermo Fisher Scientific Human/Mouse/Rat Thymosin-beta4 Recombinant Protein, PeproTech
인간, 마우스, 랫드 유래 Thymosin-beta4 재조합 단백질로, E. coli에서 발현된 고순도(≥95%) 제품. 세포 보호 및 actin 중합 조절 연구에 적합. 동결건조 형태로 제공되며, -20°C에서 보관.
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Applications
- Functional Assay (Assay-dependent)
Publications
- Miscellaneous PubMed
View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human, Mouse, Rat |
| Published species | Mouse |
| Expression System | E. coli |
| Amino Acid Sequence | RMSDKPDMAE IEKFDKSKLK KTETQEKNPL PSKETIEQEK QAGES |
| Molecular Weight | 5.2 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 95% by SDS-PAGE gel and HPLC analyses |
| Endotoxin Concentration | <1 EU/µg |
| Activity | Pretreatment of primary lung fibroblasts with recombinant Thymosin-beta4 (0.5–10 µg/ml) produces a protective effect against hydrogen peroxide-induced cell death |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage Conditions | -20°C |
Product Specific Information
- Catalog No. 140-14-1MG is provided as 2 × 500 µg (140-14-500UG)
- Recombinant Human/Murine/Rat Thymosin-beta4 is a 5.2 kDa glycoprotein containing 45 amino acid residues
- Shipped at ambient temperature
- For storage, handling, and reconstitution information, please refer to the lot-specific Certificate of Analysis
Target Information
Thymosin-beta4 is a small, actin-sequestering protein belonging to the thymosin-beta family, found at high concentrations in spleen, thymus, and peritoneal macrophages. It regulates cytoskeletal organization by forming a 1:1 complex with globular actin (G-actin), inhibiting its polymerization into filamentous actin (F-actin).
This protein is also present in brain, lungs, liver, kidneys, testes, and heart, and can be synthesized by myoblasts and fibroblasts. It is expressed at varying levels in hemopoietic and malignant lymphoid cells.
Beyond actin regulation, thymosin-beta4 influences secretion of hypothalamic luteinizing hormone-releasing hormone, inhibits macrophage migration, induces phenotypic changes in T cells during immune response, and modulates stem cell progression.
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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