Thermo Fisher Scientific CYP17A1 Polyclonal Antibody
Rabbit polyclonal antibody against human CYP17A1 for Western blot applications. Recognizes cytochrome P450 17A1 involved in steroid biosynthesis. Supplied unconjugated in liquid form, affinity-purified, and suitable for research use only.
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Applications
- Western Blot (WB): Tested dilution 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to amino acids 205–423 of Human Cytochrome P450 17A1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.81 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2547272 |
Product Specific Information
- Recommended positive controls: A431, H1299, HeLa, HepG2, Molt-4, Raji
- Predicted reactivity: Cat (81%), Rhesus Monkey (95%), Chimpanzee (99%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The CYP17A1 gene encodes a cytochrome P450 enzyme involved in steroid biosynthesis. These monooxygenases catalyze reactions in drug metabolism and synthesis of cholesterol, steroids, and other lipids. The protein localizes to the endoplasmic reticulum and exhibits both 17α-hydroxylase and 17,20-lyase activities, making it a key enzyme in the production of progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations are associated with several disorders including isolated steroid-17α-hydroxylase deficiency, pseudohermaphroditism, and adrenal hyperplasia.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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