Thermo Fisher Scientific Lass4 Polyclonal Antibody
Lass4 단백질을 검출하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody입니다. Western blot 및 IHC(P) 실험에 적합하며, 인간 시료 반응성을 가집니다. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 제공됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region derived from internal residues of human ceramide synthase 4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2636147 |
Product Specific Information
The antibody detects endogenous levels of total Lass4 protein.
Target Information
The LASS (longevity assurance homolog) family members are highly conserved from yeasts to mammals. Six members (LASS1–LASS6) have been characterized, all involved in sphingolipid synthesis.
LASS4 is a 394 amino acid endoplasmic reticulum multi-pass membrane protein that increases levels of long ceramides (C22:0, C24:0).
In CLN9-deficient cells, as seen in neuronal ceroid lipofuscinosis (NCL) or Batten disease, LASS4 can elevate ceramide levels and partially correct growth and apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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