Thermo Fisher Scientific PCBP4 Polyclonal Antibody
PCBP4 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 최적화되어 있습니다. Human 및 Mouse 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS(glycerol 포함) 용액 형태로 제공되며 -20°C에서 보관합니다.
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Applications
- Western Blot (WB): 1:200–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues near the C-terminal of human poly(rC) binding protein 4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.9 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2636156 |
Product Specific Information
This antibody detects endogenous levels of total MCG10 protein.
Target Information
MCG10 is a member of the KH-domain RNA-binding protein family, also referred to as alpha-CPs, which bind RNA with specificity for C-rich pyrimidine regions. These proteins play important roles in post-transcriptional regulation and exhibit distinct cellular distributions. MCG10 is induced by p53 and DNA damage through two p53-responsive promoter elements. Overexpression leads to suppression of cell proliferation via apoptosis and G2-M cell cycle arrest. Reduced expression of certain isoforms has been observed in various lung cancers, suggesting a tumor suppressor role. Multiple alternatively spliced isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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