Thermo Fisher Scientific PKA alpha Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1–3 µg/mL

Product Specifications

Product Specific Information

• This antibody is expected to recognize all three reported isoforms (NP_002721.1; NP_997401.1; NP_001291278.1).
• Based on the choice of the immunizing peptide, there is no expected cross-reactivity with other subunits.
• Tested in Peptide ELISA: antibody detection limit dilution 1:64,000.

Target Information

Protein kinase A (PKA, cAMP-dependent protein kinase) is a key element of a ubiquitous signaling pathway important in the cell cycle, cellular communication, memory formation, and behavior.
PKA consists of two catalytic (PKAc) and two regulatory (PKAr) subunits. Upon cAMP binding, the complex dissociates into a PKAr dimer and two activated PKAc catalytic monomers. The released PKAc can translocate into the nucleus and regulate activation of multiple nuclear hormone receptors.
PKAc-mediated activation of tonicity-dependent gene expression is cAMP independent. Humans express three PKAc subunits: alpha (ubiquitous), beta, and gamma (testes-specific).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.