Thermo Fisher Scientific PKA alpha Polyclonal Antibody
PKA alpha 단백질을 인식하는 염소 유래 다클론 항체로, Western blot에 최적화되어 있습니다. 인간 단백질에 반응하며 세 가지 isoform을 모두 인식합니다. 비결합형 액상 형태로 제공되며, -20°C에서 보관합니다.
- 카탈로그번호
- PA5143276
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1–3 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-KHKETGNHYAMK |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933915 |
Product Specific Information
- This antibody is expected to recognize all three reported isoforms (NP_002721.1; NP_997401.1; NP_001291278.1).
- Based on the choice of the immunizing peptide, there is no expected cross-reactivity with other subunits.
- Tested in Peptide ELISA: antibody detection limit dilution 1:64,000.
Target Information
Protein kinase A (PKA, cAMP-dependent protein kinase) is a key element of a ubiquitous signaling pathway important in the cell cycle, cellular communication, memory formation, and behavior.
PKA consists of two catalytic (PKAc) and two regulatory (PKAr) subunits. Upon cAMP binding, the complex dissociates into a PKAr dimer and two activated PKAc catalytic monomers. The released PKAc can translocate into the nucleus and regulate activation of multiple nuclear hormone receptors.
PKAc-mediated activation of tonicity-dependent gene expression is cAMP independent. Humans express three PKAc subunits: alpha (ubiquitous), beta, and gamma (testes-specific).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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