Thermo Fisher Scientific Phospho-PERK (Thr980) Monoclonal Antibody (G.305.4)
PERK 단백질의 Thr980 인산화 부위를 특이적으로 인식하는 단클론 항체. Western blot 및 IHC 등 다양한 응용 가능. Rabbit IgG 형식으로 제작되었으며, 액상 형태로 공급. ER 스트레스 관련 연구 및 PERK 신호전달 경로 분석에 유용.
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 19 publications |
| Immunohistochemistry (IHC) | – | View 2 publications |
| Inhibition Assays (IA) | – | View 1 publication |
| Miscellaneous PubMed (Misc) | – | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | G.305.4 |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pThr980 of mouse PERK |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 441 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10980432 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
EIF2AK3 (PERK) is one of four kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein synthesis. In the case of EIF2AK3, signaling is initiated by misfolded proteins in the endoplasmic reticulum (ER).
Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS), also known as multiple epiphyseal dysplasia with early-onset diabetes mellitus. WRS is a rare autosomal recessive disorder characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation, and other multisystem manifestations such as hepatic and renal dysfunctions, mental retardation, and cardiovascular abnormalities.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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