Thermo Fisher Scientific Nonphospho-4EBP1 (Thr46) Monoclonal Antibody (E.638.3)
Nonphospho-4EBP1 (Thr46) 단일클론 항체로, 인간·마우스·원숭이·랫트에 반응합니다. Western blot과 유세포분석에 적합하며, 비인산화 형태의 4EBP1 검출에 유용합니다. 액상 형태로 제공되며, 고순도 친화 크로마토그래피로 정제되었습니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Flow Cytometry (Flow)
- Tested Dilution: 1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | E.638.3 |
| Immunogen | Synthetic peptide corresponding to residues surrounding Thr46 of human 4E-BP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 138 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10985525 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5′ end of mRNAs. Interaction with eIF4E inhibits complex assembly and represses translation. The protein is phosphorylated in response to various signals, including UV irradiation and insulin signaling, leading to dissociation from eIF4E and activation of mRNA translation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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