Thermo Fisher Scientific HEXB Polyclonal Antibody
HEXB 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF 등 다양한 응용에 적합. 인간, 생쥐, 랫트 반응성. 고순도 Affinity chromatography 정제, -20°C 보관.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human HEXB (Accession P07686), corresponding to amino acid residues T496–L546. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850526 |
Product Specific Information
Antibody detects endogenous levels of total HEXB.
Target Information
Hexosaminidase B (HEXB), also designated beta-hexosaminidase B, is a tetramer of two β-A and two β-B chains found in lysosomes.
Mutations in the HEXB gene cause Sandhoff disease (GM2-gangliosidosis type II), leading to deficient HEXA and HEXB enzyme activity and accumulation of GM2 ganglioside in the brain.
Sandhoff disease is a rare autosomal recessive disorder causing progressive destruction of the central nervous system and is similar to Tay-Sachs disease, though more severe.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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