Thermo Fisher Scientific IMPDH2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 215-514 of human IMPDH2 (NP_000875.2). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:IMPDH2,uniProtId:P12268-1,ncbiNodeId:9606,antigenRange:215-514,antigenLength:514,antigenImageFileName:PA5-120380_IMPDH2_P12268-1_Rabbit.svg,antigenImageFileNamePDP:PA5-120380_IMPDH2_P12268-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.70 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2913952

Product Specific Information

Positive test controls include: LO2, HeLa, Mouse liver. The target is usually found in the following locations: Cytoplasm, Nucleus.

Immunogen sequence: DDELVAIIAR TDLKKNRDYP LASKDAKKQL LCGAAIGTHE DDKYRLDLLA QAGVDVVVLD SSQGNSIFQI NMIKYIKDKY PNLQVIGGNV VTAAQAKNLI DAGVDALRVG MGSGSICITQ EVLACGRPQA TAVYKVSEYA RRFGVPVIAD GGIQNVGHIA KALALGASTV MMGSLLAATT EAPGEYFFSD GIRLKKYRGM GSLDAMDKHL SSQNRYFSEA DKIKVAQGVS GAVQDKGSIH KFVPYLIAGI QHSCQDIGAK SLTQVRAMMY SGELKFEKRT SSAQVEGGVH SLHSYEKRLF

Target Information

This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5-monophosphate into xanthine-5-monophosphate, which is then converted into guanosine-5`-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.