Thermo Fisher Scientific SREBP1 Polyclonal Antibody
SREBP1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB, ICC/IF, ELISA에 사용 가능. 인간, 마우스, 랫트 시료 반응성. 고순도 Affinity 정제, -20°C 보관. 지질 및 콜레스테롤 대사 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 200–310 of human SREBF1 (NP_004167.3) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.43 mg/mL |
| Purification | Affinity Chromatography |
| Storage buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2913950 |
Product Specific Information
- Positive test controls: A-549, MCF7, U-87MG, Mouse liver
- Subcellular localization: COPII-coated vesicle membrane, Cytoplasmic vesicle, Endoplasmic reticulum membrane, Golgi apparatus membrane, Multi-pass membrane protein, Nucleus
Immunogen sequence:
SLHTQVQSVV PQQLLTVTAA PTAAPVTTTV TSQIQQVPVL LQPHFIKADS LLLTAMKTDG ATVKAAGLSP LVSGTTVQTG PLPTLVSGGT ILATVPLVVD AEKLPINRLA A
Target Information
Sterol regulatory element-binding proteins (SREBPs) are transcription factors belonging to the basic helix-loop-helix leucine zipper family. Three isoforms exist in mammals—SREBP-1a, SREBP-1c (ADD1), and SREBP-2—with distinct regulatory and functional roles.
SREBPs are synthesized as 120 kDa precursors in the endoplasmic reticulum (ER) membrane. Upon activation, they translocate to the Golgi, where proteolytic cleavage generates a 60–78 kDa mature transcriptionally active fragment.
In liver and adipose tissues, SREBPs regulate lipid and cholesterol accumulation by inducing gene transcription related to these pathways. SREBP-1 primarily controls triglyceride synthesis, whereas SREBP-2 is more associated with cholesterol biosynthesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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