Thermo Fisher Scientific ALK Monoclonal Antibody (OTI5C8), TrueMAB
인간 ALK 단백질을 인식하는 마우스 단클론 항체로 Western blot에 최적화됨. 동결건조 형태로 제공되며 재구성 후 약 1 mg/mL 농도로 사용 가능. 뇌 발달 관련 연구 및 ALK 변이 암 연구에 적합. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5C8 |
| Immunogen | Full length human recombinant protein of human ALK produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform additional desalting using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and plays a critical role in brain development.
Mutations, rearrangements, and amplifications in the ALK gene are associated with various tumors such as anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer.
Chromosomal rearrangement between ALK (chromosome 2) and NPM (chromosome 5) leads to the oncogenic NPM-ALK fusion gene.
ALK encodes a receptor protein-tyrosine kinase with a transmembrane and extracellular domain, showing high similarity to LTK.
It is essential for neuronal development and signaling in the nervous system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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