Thermo Fisher Scientific TRA1 Monoclonal Antibody (1A8)
Human GRP94 단백질을 인식하는 Mouse IgM 단클론 항체로, Western blot 및 ELISA에 적합. TRA1 full-length recombinant protein을 면역원으로 사용. 액상 형태, 무보존제, -20°C 보관. 연구용으로만 사용 가능.
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Thermo Fisher Scientific TRA1 Monoclonal Antibody (1A8)
Applications and Tested Dilution
- Western Blot (WB): 1:500–1:1,000
- ELISA: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgM, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1A8 |
| Immunogen | TRA1 (AAH09195.1, 1–315 a.a) full-length recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MRALWVLGLC CVLLTFGSVR ADDEVDVDGT VEEDLGKSRE GSRTDDEVVQ REEEAIQLDG LNASQIRELR EKSEKFAFQA EVNRMMKLII NSLYKNKEIF LRELISNASD ALDKIRLISL TDENALSGNE ELTVKIKCDK EKNLLHVTDT GVGMTREELV KNLGTIAKSG TSEFLNKMTE AQEDGQSTSE LIGQFGVGFY SAFLVADKVI VTSKHNNDTQ HIWESDSNEF SVIADPRGNT LGRGTTITLV LKEEASDYLE LDTIKNLVKK YSQFINFPIY VWSSKTETVE EPMEEEEAAK EEKEESDDEA AARRR
Target Information
GRP94 is a 803 amino acid protein belonging to the heat shock protein 90 family. It functions as a molecular chaperone involved in processing and transport of secreted proteins. GRP94 and its N-terminal fragment stimulate CTL expansion and maturation of human monocyte-derived dendritic cells (MDDC).
It plays roles in innate and acquired immunity, dendritic cell maturation and chemotaxis, antibody production, and cross-priming. GRP94 acts as a peptide acceptor in the endoplasmic reticulum and assists peptide loading of MHC class I molecules. Expression of GRP94 suppresses A23187-induced apoptosis and stabilizes calcium homeostasis. GRP94 is expressed in melanoma, liver metastases of colon carcinoma, and human gastric carcinoma BGC-823 cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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