Thermo Fisher Scientific PSMD2 Polyclonal Antibody
PSMD2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF에 사용 가능. Human, Mouse, Rat 반응성. Affinity chromatography로 정제되었으며, 1 mg/mL 농도의 액상 형태. 연구용으로 4°C 또는 -20°C에서 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:1,500 |
| Immunocytochemistry (ICC/IF) | 1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein within Human PSMD2 aa 1–200/908 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.1% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3094042 |
Product Specific Information
- Positive control: 293T, Jurkat, HeLa, NIH/3T3 cell lysates; mouse heart, rat testis, rat heart, rat large intestine, human lung carcinoma, human striated muscle, and SiHa tissues.
- Predicted band size: 100 kDa
- Subcellular Location: Cytosol, extracellular exosome, extracellular region, nucleoplasm, nucleus, proteasome storage granule.
Target Information
The 26S proteasome is a multicatalytic proteinase complex composed of a 20S core and a 19S regulator. The 20S core consists of four rings of 28 subunits (two alpha and two beta rings), while the 19S regulator includes a base with ATPase and non-ATPase subunits and a lid with up to ten non-ATPase subunits. Proteasomes are abundant in eukaryotic cells and degrade peptides in an ATP/ubiquitin-dependent, non-lysosomal pathway.
The immunoproteasome variant processes class I MHC peptides. The PSMD2 gene encodes a non-ATPase subunit of the 19S regulator lid, which may also participate in the TNF signaling pathway through interaction with the TNF type 1 receptor. A pseudogene exists on chromosome 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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