Thermo Fisher Scientific CDK9 Polyclonal Antibody
CDK9 단백질을 인식하는 Goat 유래 Polyclonal 항체로, Western blot과 Peptide ELISA에 적합합니다. 0.5 mg/mL 농도의 액상 형태이며, TBS buffer(pH 7.3)와 0.5% BSA를 포함합니다. 세포 성장 및 전사 조절 연구용으로 사용됩니다.
- 카탈로그번호
- PA5143307
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1–3 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence RTKASPYNRCKGS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933946 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:1,000.
Target Information
CDK9 is a serine/threonine kinase which, when complexed with CyclinT1, forms an active holoenzyme complex. This complex plays a key role in regulating the eukaryotic cell cycle. CDK9 is coexpressed and copurified with CyclinT1 and regulates cytokine-inducible transcription networks by facilitating promoter recognition of target transcription factors. It promotes RNA synthesis in genetic programs for cell growth, differentiation, and viral pathogenesis. The CDK9/cyclin-K complex also has kinase activity towards CTD of RNAPII and can substitute for CDK9/cyclin-T P-TEFb in vitro. Chronic activation of CDK9 causes cardiac myocyte enlargement leading to cardiac hypertrophy and predisposition to heart failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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