Thermo Fisher Scientific mGluR5 Polyclonal Antibody
mGluR5 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 IHC(P) 실험에 적합합니다. 다양한 종에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS 버퍼에 0.1% sodium azide가 포함되어 있습니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | 4–13 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bat, Bovine, Dog, Horse, Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 20 amino acid peptide from C-terminus of human GRM5 / MGLUR5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551193 |
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey, Marmoset, Mouse, Rat, Dog, Bat, Bovine, Horse (100%), Platypus (95%).
Target Information
GRK1 is a member of the guanine nucleotide protein-coupled (G protein) receptor kinase subfamily of the Serine/Threonine kinase family. GRK1 phosphorylates rhodopsin and initiates its deactivation. G protein-mediated phosphorylation promotes the binding of arrestin, which removes the receptor from the G-protein and terminates the receptor signal chain. GRK1 is farnesylated to promote membrane association. Studies have shown that GRK1 is inhibited by recoverin, a calcium-binding protein. Diseases associated with GRK1 protein dysfunction include Oguchi Disease-2 and Hereditary Night Blindness.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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