Thermo Fisher Scientific AXL Monoclonal Antibody (M047)
AXL 단백질을 인식하는 Mouse IgG1 단일클론 항체로, WB, ICC/IF, ELISA, IP에 사용 가능. 인간 시료 반응성. 단백질 G로 정제된 액상 형태이며, -20°C에서 보관. 암 연구 및 세포 신호전달 연구에 유용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| ELISA | Assay-dependent |
| Immunoprecipitation (IP) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | M047 |
| Immunogen | Clone (M047) was generated from a recombinant protein including the extracellular region of human Axl protein. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 1 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2942629 |
Product Specific Information
Clone M047 mouse monoclonal antibody detects a 140 kDa protein on SDS-PAGE (native or denatured) immunoblots of human A549, NCI-H1915, and MDA-MB-231 carcinoma samples.
This antibody detects Axl in membranes and cytoplasm of MDA-MB-231 cells after immunocytochemical labeling.
It is validated for use in Western blot, immunoprecipitation, immunocytochemistry, and ELISA capture assays.
Target Information
AXL is a chronic myelogenous leukemia-associated oncogene also linked to colon cancer and melanoma.
The AXL protein is a receptor tyrosine kinase that transduces extracellular matrix signals into cytoplasmic responses by binding growth factors such as GAS6.
It regulates cell proliferation and participates in apoptotic cell clearance through TAM receptor signaling.
Deficiency of TAM receptors in mice causes degenerative and autoimmune phenotypes similar to systemic lupus erythematosus.
AXL may also function as a potential entry receptor for filoviruses and serves as a marker for Siglec6+/Axl+ dendritic cells.
Its expression can be upregulated by TLR ligands (e.g., LPS, poly I:C), and soluble Axl levels may indicate inflammation or cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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