Thermo Fisher Scientific SOCS3 Polyclonal Antibody
SOCS3 단백질을 표적하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, ICC/IF, ELISA에 적합하며 인간, 마우스, 랫트 반응성. 고순도 친화 크로마토그래피 정제, 액상 형태로 안정적인 저장 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 101–225 of human SOCS3 (NP_003946.3) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.39 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901130 |
Product Specific Information
- Positive Samples: Mouse lung, Mouse spleen
- Immunogen sequence:
SFSLQSDPRS TQPVPRFDCV LKLVHHYMPP PGAPSFPSPP TEPSSEVPEQ PSAQPLPGSP PRRAYYIYSG GEKIPLVLSR PLSSNVATLQ HLCRKTVNGH LDSYEKVTQL PGPIREFLDQ YDAPL
Target Information
Cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules termed SOCS (Suppressor of Cytokine Signaling). There are eight recognized members of the SOCS family: SOCS-1, 2, 3, 4, 5, 6, 7, and CIS. Structurally, SOCS proteins consist of an N-terminal variable region, a central SH2 domain, and a C-terminal SOCS box motif. These proteins form part of a classical negative feedback loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. Transcription of SOCS genes occurs rapidly in response to cytokines, and each member inhibits signaling through distinct mechanisms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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