Thermo Fisher Scientific RAB8A Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.1–0.5 µg/mL

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 0.5–1 µg/mL

Product Specifications

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Target Information

The protein encoded by this gene is a member of the RAS superfamily, consisting of small GTP/GDP-binding proteins (~200 amino acids). RAB/YPT family proteins are involved in transport from the endoplasmic reticulum to the Golgi and plasma membrane.
RAB8A shares 97%, 96%, and 51% similarity with dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively. It contains four GTP/GDP-binding sites common to RAS proteins and a C-terminal CAAX motif typical of many RAS family members but absent in YPT1 and most RAB proteins.
Although isolated as a transforming gene from a melanoma cell line, no direct link between MEL and malignant melanoma has been demonstrated. The gene is located 800 kb distal to MY09B on chromosome 19p13.1.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.