Thermo Fisher Scientific BARD1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Keep as concentrated solution.
• Positive Control: A431, A431 nuclear extract.
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

This gene encodes a protein that interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the two most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in various proteins regulating cell growth, including products of tumor suppressor genes and proto-oncogenes. This protein also contains three tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.