ELK Biotechnology Flt-1 rabbit pAb
Flt-1(FLT1/VEGFR1) 단백질을 인식하는 토끼 폴리클로날 항체로, 인간, 마우스, 랫트 시료에 반응합니다. WB, IHC, IF, ELISA에 사용 가능하며, 혈관신생 및 혈관형성 연구에 적합합니다. -20°C에서 1년 보관 가능합니다.
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Flt-1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Flt-1 rabbit pAb |
| Alternative Names | FLT1; FLT; FRT; VEGFR1; Vascular endothelial growth factor receptor 1; VEGFR-1; Fms-like tyrosine kinase 1; FLT-1; Tyrosine-protein kinase FRT; Tyrosine-protein kinase receptor FLT; FLT; Vascular permeability factor receptor |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human VEGFR1. AA range: 1016–1065 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 150 kD |
| GeneID (Human) | 2321 |
| Human Swiss-Prot No. | P17948 |
| Cellular Localization | [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Endosome. Autophosphorylation promotes ubiquitination and endocytosis. [Isoform 2]: Secreted. [Isoform 3]: Secreted. [Isoform 4]: Secreted. [Isoform 5]: Cytoplasm. [Isoform 6]: Cytoplasm. [Isoform 7]: Cytoplasm. |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B, and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells, and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia. [provided by RefSeq, May 2009]
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