ELK Biotechnology CYP2A6 rabbit pAb
CYP2A6 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IF, ELISA에 사용 가능. 인간 Cytochrome P450 2A6 유래 펩타이드로 면역화. 약물 대사 연구에 적합하며, -20°C에서 1년 보관 가능.
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제품명
CYP2A6 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | CYP2A6; CYP2A3; Cytochrome P450 2A6; 1; 4-cineole 2-exo-monooxygenase; CYPIIA6; Coumarin 7-hydroxylase; Cytochrome P450 IIA3; Cytochrome P450(I) |
| Applications | WB; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Cytochrome P450 2A6 (AA range: 1–50) |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 56 kD |
| Gene ID (Human) | 1548 |
| Human Swiss-Prot No. | P11509 |
| Cellular Localization | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. |
| Species Reactivity | Human; Rat; Mouse; Chicken |
Background
The CYP2A6 gene encodes a member of the cytochrome P450 superfamily of enzymes. These monooxygenases catalyze many reactions involved in drug metabolism and the synthesis of cholesterol, steroids, and other lipids. The protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. It hydroxylates coumarin and metabolizes nicotine, aflatoxin B1, nitrosamines, and various pharmaceuticals. Certain allelic variants result in a poor metabolizer phenotype, reducing metabolism efficiency for coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B, and CYP2F subfamilies on chromosome 19q. Formerly referred to as CYP2A3, it has been renamed CYP2A6. (RefSeq, Jul 2008)
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