ELK Biotechnology FGFR-3 rabbit pAb
FGFR-3 rabbit pAb는 인간 FGFR3 단백질을 인식하는 고품질 폴리클로날 항체로, WB, IHC, IF, ELISA 등에 적합합니다. 합성 펩타이드로부터 면역생성되었으며, 95–130kD 밴드를 검출합니다. 인간, 마우스, 랫트 시료에 반응하며 -20°C에서 1년 보관 가능합니다.
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제품명
FGFR-3 rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Product name | FGFR-3 rabbit pAb |
| Alternative Names | FGFR3; JTK4; Fibroblast growth factor receptor 3; FGFR-3; CD antigen CD333 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human FGFR3. AA range: 131–180 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 95–130 kD |
| GeneID (Human) | 2261 |
| Human Swiss-Prot No | P22607 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치 (Cellular Localization)
- Isoform 1: Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Endoplasmic reticulum. The activated receptor is rapidly internalized and degraded. Detected in intracellular vesicles after internalization of the autophosphorylated receptor.
- Isoform 2: Cell membrane; Single-pass type I membrane protein.
- Isoform 3: Secreted.
- Isoform 4: Cell membrane; Single-pass type I membrane protein.
Background
This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors, initiating downstream signaling cascades that regulate mitogenesis and differentiation. This family member binds acidic and basic fibroblast growth hormones and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia.
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