ELK Biotechnology Latrophilin-1 rabbit pAb
Latrophilin-1 단백질을 인식하는 토끼 폴리클로날 항체로, WB, ELISA, IHC에 사용 가능. 인간, 생쥐, 랫트 반응성. 세포막 및 시냅스 부위에 존재하는 LPHN1 단백질 검출에 적합. -20℃에서 1년 보관 가능.
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Latrophilin-1 Rabbit Polyclonal Antibody
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Latrophilin-1 rabbit pAb |
| Alternative Names | LPHN1; KIAA0821; LEC2; Latrophilin-1; Calcium-independent alpha-latrotoxin receptor 1; CIRL-1; Lectomedin-2 |
| Applications | WB; ELISA; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300; ELISA 1:2000–20000 |
| Immunogen | The antiserum was produced against synthesized peptide derived from human LPHN1 (AA range: 561–610) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 22859 |
| Human Swiss-Prot No. | O94910 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. Cell projection (axon, growth cone); Cell junction (synapse, presynaptic cell membrane, synaptosome). Colocalizes with TENM2 on the cell surface, across intercellular junctions, and on nerve terminals near synaptic clefts. |
Background
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits — a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs — being non-covalently bound at the cell membrane.
Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.
[Provided by RefSeq, Oct 2008]
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