ELK Biotechnology Intestinal Cell Kinase (phospho Tyr159) rabbit pAb
Intestinal Cell Kinase (phospho Tyr159) rabbit pAb는 인간 ICK의 Tyr159 인산화 부위를 인식하는 폴리클로날 항체입니다. WB, ELISA, IHC에 사용 가능하며, 세포 내 신호전달 연구에 적합합니다. -20°C에서 1년간 안정적으로 보관 가능합니다.
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Intestinal Cell Kinase (phospho Tyr159) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Intestinal Cell Kinase (phospho Tyr159) rabbit pAb |
| Alternative Names | ICK; KIAA0936; Serine/threonine-protein kinase ICK; Intestinal cell kinase; hICK; Laryngeal cancer kinase 2; LCK2; MAK-related kinase; MRK |
| Applications | WB; ELISA; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300; ELISA 1:2000–20000 |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ICK around the phosphorylation site of Tyr159. AA range: 125–174 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 71 kD |
| Gene ID (Human) | 22858 |
| Human Swiss-Prot No. | Q9UPZ9 |
| Species Reactivity | Human; Mouse; Rat |
Cellular Localization
Nucleus, cytoplasm (cytosol), cell projection (cilium), cytoskeleton (cilium basal body). Also found at the ciliary tip (PubMed:24797473). Nuclear localization observed with GFP-tagged construct in transfected HeLa cells (PubMed:12103360, PubMed:19185282). Isoform 2 shows predominant cytoplasmic localization with N-terminally GFP-tagged construct.
Background
Eukaryotic protein kinases are enzymes belonging to a large family sharing a conserved catalytic core common to both serine/threonine and tyrosine kinases. The ICK gene encodes an intestinal serine/threonine kinase with a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and plays a key role in epithelial cell proliferation and differentiation. Alternative splicing at this locus produces two variants encoding the same isoform (RefSeq, Jul 2008).
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