ELK Biotechnology KPI-2 rabbit pAb
인간 LMTK2 유래 펩타이드로 제작된 rabbit polyclonal antibody. WB, IHC, IF, ELISA에 사용 가능하며 다양한 종(Human, Rat, Mouse)에 반응. 세포막 단백질 검출에 적합하며 신경 성장 및 세포막 수송 연구에 활용 가능.
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- pk
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제품명
KPI-2 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | LMTK2; AATYK2; BREK; KIAA1079; KPI2; LMR2; Serine/threonine-protein kinase LMTK2; Apoptosis-associated tyrosine kinase 2; Brain-enriched kinase; hBREK; CDK5/p35-regulated kinase; CPRK; Kinase/phosphatase/inhibitor 2; Lemur tyrosine kinase 2 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 Immunofluorescence: 1/200–1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human LMTK2 (AA range: 651–700) |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 164 kDa |
| Gene ID (Human) | 22853 |
| Human Swiss-Prot No. | Q8IWU2 |
| Cellular Localization | Membrane; Multi-pass membrane protein |
| Species Reactivity | Human; Rat; Mouse |
Background
The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosphorylates other proteins and is itself also phosphorylated when interacting with the cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein is involved in nerve growth factor (NGF)-TrkA signaling and plays a critical role in endosomal membrane trafficking. Mouse studies suggest an essential role of this protein in spermatogenesis.
[provided by RefSeq, Oct 2009]
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