ELK Biotechnology FGFR-4 (phospho Tyr642) rabbit pAb
FGFR-4 (phospho Tyr642) rabbit polyclonal antibody로 인간, 마우스, 랫트에서 반응. Western blot과 ELISA에 적합하며, 세포막 및 내막계 위치 단백질 검출에 유용. 고순도 IgG, 1 mg/ml 농도, -20°C에서 1년 보관 가능.
- 카탈로그번호
- ES5251-xxxxx (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다ELK Biotechnology · ELK Biotechnology FGFR-4 (phospho Tyr642) rabbit pAb
제품명
FGFR-4 (phospho Tyr642) rabbit pAb
공급업체
ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | FGFR4; JTK2; TKF; Fibroblast growth factor receptor 4; FGFR-4; CD antigen CD334 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized phospho-peptide around the phosphorylation site of human FGFR-4 (phospho Tyr642) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 90 kD |
| GeneID (Human) | 2264 |
| Human Swiss-Prot No | P22455 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein; Endosome; Endoplasmic reticulum; Internalized from the cell membrane to recycling endosomes and back; Isoform 2: Secreted; Isoform 3: Cytoplasm |
Background
The protein encoded by this gene belongs to the fibroblast growth factor receptor (FGFR) family, which shows high amino acid sequence conservation among members and across evolution. FGFR family members differ in ligand affinities and tissue distribution. A full-length FGFR-4 protein consists of:
- Extracellular region with three immunoglobulin-like domains
- Single hydrophobic membrane-spanning segment
- Cytoplasmic tyrosine kinase domain
The extracellular domain interacts with fibroblast growth factors, triggering downstream signaling cascades that influence mitogenesis and differentiation. The gene structure contains 18 exons, unlike FGFR1–3 which have 19–20. Although alternative splicing occurs, there is no evidence that the C-terminal half of IgII is affected.
ELK Biotechnology 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.