ELK Biotechnology PYK2 (phospho Tyr580) rabbit pAb
PYK2 (phospho Tyr580) rabbit pAb는 인간, 마우스, 랫트에 반응하는 폴리클로날 항체입니다. WB, IHC, IF, ELISA에 사용 가능하며 Tyr580 인산화 부위 펩타이드로 면역생성되었습니다. 세포막 및 세포질에 위치하며 130kDa 밴드를 검출합니다.
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제품명
PYK2 (phospho Tyr580) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | PTK2B; FAK2; PYK2; RAFTK; Protein-tyrosine kinase 2-beta; Calcium-dependent tyrosine kinase; CADTK; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; CAK-beta; CAKB; Focal adhesion kinase 2; FADK 2; Pro |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human PYK2 around the phosphorylation site of Tyr580 (AA range: 546–595) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 130 kDa |
| Gene ID (Human) | 2185 |
| Human Swiss-Prot No. | Q14289 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cytoplasm; perinuclear region; cell membrane (cytoplasmic side); cell junction (focal adhesion); lamellipodium; cell cortex; nucleus. Interaction with NPHP1 induces membrane association. Colocalizes with integrins at the cell periphery. |
Background
This gene encodes a cytoplasmic protein tyrosine kinase involved in calcium-induced regulation of ion channels and activation of the MAP kinase signaling pathway. The encoded protein may act as an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and downstream signals regulating neuronal activity. It undergoes rapid tyrosine phosphorylation and activation in response to increased intracellular calcium, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. The protein binds CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. It belongs to the FAK subfamily of protein tyrosine kinases.
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