ELK Biotechnology PYK2 (phospho Tyr881) rabbit pAb
인산화 Tyr881 부위에 특이적인 PYK2 rabbit polyclonal antibody. WB, IHC, IF, ELISA에 사용 가능. 인간, 마우스, 랫트 반응성. 세포막 및 세포질 국소화 단백질 검출에 적합. -20°C에서 1년 보관 가능.
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PYK2 (phospho Tyr881) rabbit pAb
제품 개요
ELK Biotechnology의 PYK2 (phospho Tyr881) rabbit polyclonal antibody는 인간 PYK2 단백질의 Tyr881 인산화 부위를 인식하도록 제작된 항체입니다. 다양한 응용 분야에서 신호전달 관련 단백질의 인산화 상태 분석에 활용할 수 있습니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | PYK2 (phospho Tyr881) rabbit pAb |
| Alternative Names | PTK2B; FAK2; PYK2; RAFTK; Protein-tyrosine kinase 2-beta; Calcium-dependent tyrosine kinase; CADTK; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; CAK-beta; CAKB; Focal adhesion kinase 2; FADK 2; Pro |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000, IHC: 1/100–1/300, ELISA: 1/5000. Not yet tested in other applications. |
| Immunogen | Synthesized peptide derived from human PYK2 around the phosphorylation site of Tyr881 (AA 847–896). |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 116 kD |
| GeneID (Human) | 2185 |
| Human Swiss-Prot No. | Q14289 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cytoplasm; perinuclear region; cell membrane (cytoplasmic side); cell junction (focal adhesion); cell projection (lamellipodium); cytoplasm (cell cortex); nucleus. Interaction with NPHP1 induces membrane association. Colocalizes with integrins at the cell periphery. |
Background
This gene encodes a cytoplasmic protein tyrosine kinase involved in calcium-induced regulation of ion channels and activation of the MAP kinase signaling pathway. The encoded protein acts as a signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and downstream signals regulating neuronal activity. It undergoes rapid tyrosine phosphorylation and activation in response to increased intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. The protein binds CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. It belongs to the FAK subfamily of protein tyrosine kinases.
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