ELK Biotechnology Akt (phospho Ser124) rabbit pAb
Akt (phospho Ser124) rabbit pAb는 인간, 마우스, 랫트 시료에 반응하는 다클론 항체로 WB, IHC, IF, ELISA에 사용 가능합니다. Ser124 인산화 부위를 인식하며, 세포 내 Akt 활성화 연구에 적합합니다. -20°C에서 1년 보관 가능합니다.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다ELK Biotechnology · ELK Biotechnology Akt (phospho Ser124) rabbit pAb
Akt (phospho Ser124) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Akt (phospho Ser124) rabbit pAb |
| Alternative Names | AKT1; PKB; RAC; RAC-alpha serine/threonine-protein kinase; Protein kinase B; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alpha |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Akt around the phosphorylation site of Ser124 (AA range: 90–139) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 56 kDa |
| Gene ID (Human) | 207 |
| Human Swiss-Prot No | P31749 |
| Species Reactivity | Human; Mouse; Rat |
Cellular Localization
Cytoplasm, nucleus, and cell membrane. Translocates to the nucleus after activation by integrin-linked protein kinase 1 (ILK1). Nuclear translocation is enhanced by interaction with TCL1A. Phosphorylation on Tyr-176 by TNK2 results in localization to the cell membrane, where further phosphorylations on Thr-308 and Ser-473 lead to activation. The activated form translocates to the nucleus and colocalizes with WDFY2 in intracellular vesicles (PubMed:16792529).
Background
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved fibroblasts. AKT1 and AKT2 are activated by platelet-derived growth factor, a process dependent on phosphatidylinositol 3-kinase. In the nervous system, AKT is a key mediator of growth factor-induced neuronal survival, preventing apoptosis by phosphorylating and inactivating apoptotic components. Mutations in AKT1 are associated with Proteus syndrome. Multiple alternatively spliced transcript variants exist (RefSeq, Jul 2011).
ELK Biotechnology 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.