ELK Biotechnology ErbB-3 rabbit pAb
ErbB-3 단백질을 인식하는 토끼 폴리클로날 항체. Western blot, IHC, IF, ELISA에 적합. 인간, 생쥐, 랫트 반응성. HER3 관련 신호전달 연구 및 암 발현 분석에 활용 가능.
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제품명
ErbB-3 rabbit pAb
제품 설명
ErbB-3 단백질(HER3)을 인식하는 토끼 폴리클로날 항체로, 다양한 종(인간, 생쥐, 랫트)에 반응합니다. EGFR 패밀리 단백질 연구, 세포 신호전달 및 암 연구에 유용합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | ErbB-3 rabbit pAb |
| Alternative Names | ERBB3; HER3; Receptor tyrosine-protein kinase erbB-3; Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human HER3 (AA range: 1–50) |
| Host Species | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 148 kDa |
| Gene ID (Human) | 2065 |
| Human Swiss-Prot No. | P21860 |
| Cellular Localization | [Isoform 1]: Cell membrane; Single-pass type I membrane protein. [Isoform 2]: Secreted |
| Species Reactivity | Human; Rat; Mouse |
Background
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but lacks an active kinase domain. It can bind ligands but does not transmit signals via phosphorylation. However, it forms heterodimers with other EGFR family members possessing kinase activity, leading to activation of pathways for cell proliferation and differentiation. Amplification or overexpression of this gene has been observed in various cancers, including prostate, bladder, and breast tumors. Alternative splice variants encode different isoforms, one of which is secreted and modulates the activity of the membrane-bound form.
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