ELK Biotechnology ErbB-3 rabbit pAb

제품명

ErbB-3 rabbit pAb

제품 설명

ErbB-3 단백질(HER3)을 인식하는 토끼 폴리클로날 항체로, 다양한 종(인간, 생쥐, 랫트)에 반응합니다. EGFR 패밀리 단백질 연구, 세포 신호전달 및 암 연구에 유용합니다.

제품 정보

Background

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but lacks an active kinase domain. It can bind ligands but does not transmit signals via phosphorylation. However, it forms heterodimers with other EGFR family members possessing kinase activity, leading to activation of pathways for cell proliferation and differentiation. Amplification or overexpression of this gene has been observed in various cancers, including prostate, bladder, and breast tumors. Alternative splice variants encode different isoforms, one of which is secreted and modulates the activity of the membrane-bound form.