ELK Biotechnology Casein Kinase Iα (phospho Thr321) rabbit pAb

Casein Kinase Iα (phospho Thr321) rabbit pAb

제품 개요

본 항체는 인간 Casein Kinase Iα 단백질의 Thr321 인산화 부위를 인식하는 rabbit polyclonal antibody입니다. 다양한 응용 실험(WB, IHC, IF, ELISA)에 사용 가능하며, 세포 내 여러 구조에서의 단백질 위치를 연구하는 데 적합합니다.

제품 정보

세포 내 위치

• Cytoplasm
• Cytoskeleton (microtubule organizing center, centrosome)
• Chromosome (centromere, kinetochore)
• Nucleus speckle
• Cytoplasm (cilium basal body, spindle)
• Localizes to the centrosome in interphase cells and to kinetochore fibers during mitosis
• Also recruited to the keratin cytoskeleton (PubMed:23902688)

단백질 기능 및 특징

• Catalytic activity: ATP + a protein → ADP + a phosphoprotein
• Function: Casein kinases preferentially phosphorylate acidic proteins such as caseins and can modify various substrates. Participates in Wnt signaling and phosphorylates CTNNB1 on Ser-45.
• Similarity: Belongs to the protein kinase superfamily, CK1 Ser/Thr protein kinase family, Casein kinase I subfamily.
• Domain: Contains one protein kinase domain.
• Subunit: Monomer; interacts with the Axin complex.